Welcome to the Dustin Baldridge lab

Our lab studies the genetic basis of rare Mendelian disorders and develops high-throughput cell-based assays and functional genomics techniques to experimentally characterize the effects of clinically observed variants. We also use genome sequencing and informatics approaches to increase the usability of genetic data at the bedside and improve clinical care. 

Come learn with us…

Are you interested in joining our team?

Please contact Dustin with any questions.

Dustin Baldridge, MD, PhD

Principal Investigator

Dustin Baldridge, MD, PhD, is a board-certified pediatrician conducting full-time translational genomics research at Washington University in St. Louis, where he is an Assistant Professor of Pediatrics in the Division of Genetics and Genomic Medicine. Baldridge is committed to helping children with underlying genetic disorders receive a molecular diagnosis.

He completed his combined MD/PhD training at Baylor College of Medicine, postgraduate training in Pediatrics at Washington University School of Medicine, and one year of service as a Chief Resident at St. Louis Children’s Hospital. As a successfully funded NHGRI K08 awardee focused in the areas of genomic medicine and functional genomics, he is leading a team that is solving a fundamental problem in human genetics, namely the overwhelming number of variants of uncertain significance (VUS) generated via exome and genome sequencing.

Baldridge also serves as a co-investigator for the Washington University Model Organism Screening Center (wuMOSC) of the Undiagnosed Diseases Network (UDN), where his responsibilities include assessing candidate gene variants from a human genetics perspective and assisting in the identification of the most appropriate model organism (worm, fly, or fish) in which to model the variant.


Congratulations to Jaeden!

Jaeden Flury has been accepted into PhD programs at the following schools: Washington University in St. Louis, Baylor College of Medicine, UT Southwestern Medical Center, University of Southern California, University of Michigan, St. Jude Children’s Research Hospital, Indiana University. She is still in the process of making her decision. Congratulations!

With generous support from:

National Human Genome Research Institute

Undiagnosed Diseases Network

Children’s Discovery Institute

Institute of Clinical and Translational Sciences

Intellectual and Developmental Disabilities Research Center